The gut microbiota and inflammatory bowel diseases
نویسندگان
چکیده
منابع مشابه
The Bowel Microbiota and Inflammatory Bowel Diseases
The human bowel contains a large and biodiverse bacterial community known as the microbiota or microbiome. It seems likely that the microbiota, fractions of the microbiota, or specific species comprising the microbiota provide the antigenic fuel that drives the chronic immune inflammation of the bowel mucosa that is characteristic of Crohn's disease and ulcerative colitis. At least twenty years...
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The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a genetic predisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of "dysbiosis", with alterations of the gut microbial...
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Rapid environmental transition and modern lifestyles are likely driving changes in the biodiversity of the human gut microbiota. With clear effects on physiologic, immunologic, and metabolic processes in human health, aberrations in the gut microbiome and intestinal homeostasis have the capacity for multisystem effects. Changes in microbial composition are implicated in the increasing propensit...
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Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role in the pathogenesis of inflammatory bowel diseases (IBD). The brain-gut axis involves interactions between the neural components including; a) the autonomic nervous system, b) the central nervous system c) the stress system (hypothalamic-pituitary adrenal axis, HPA) and d) the (i.e. gastro-intestinal) cort...
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The intestine and the intestinal immune system have evolved through a symbiotic homeostasis under which a highly diverse microbial flora is maintained in the gastrointestinal tract while pathogenic bacteria are recognized and eliminated. Disruption of the balance between the immune system and the gut microbiota results in the development of multiple pathologies in humans. Inflammatory bowel dis...
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ژورنال
عنوان ژورنال: Translational Research
سال: 2017
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2016.06.002